Figure 5From: High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibitionA. Effects of protein kinase C inhibitor (PKCi) chelerythrine on inotropic responses (developed pressure) of perfusate calcium 1.5 to 2.5 mM (left), 2.5 to 3.5 mM (middle), and dobutamine (right). B. Effects of PKCi with perfusate calcium 2.5 to 3.5 mM (left) on peak systolic intracellular calcium, and basal diastolic calcium (right). Baseline controls values (perfusate calcium 1.5, 2.0 or 2.5 mM) for these experiments include those experiments with addition of chelerythrine to the higher perfusate calcium or dobutamine after control measurements, combined also with those experiments without chelerythrine. * p < 0.05, and ** p < 0.005.Back to article page