Figure 5
From: Matrix metalloproteinases 2 and 9 increase permeability of sheep pleura in vitro
TIMP2 reverses partially the effect of MMP9 on pleural permeability. TIMP2 was added at concentration 200 ng/ml on the apical and basolateral side of parietal(a) and visceral pleura(b). MMP9 was added at the same time at concentration 0.1 ng/ml. TIMP2 seems to prevent partially the decline in RTM induced by MMP9 on the 40th minute of the experimental procedure. Data are given as mean ± SD. n = 6 for MMP9, n = 3 for combined MMP9 and TIMP2, n = 3 for TIMP2.