Figure 4
From: Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression
Effects of adrenalectomy, streptozotocin injection and fasting on levels of hypothalamic gene expression. (A) Hypothalamic AGRP mRNA is induced by streptozotocin injection, however the induction is partially blocked by adrenalectomy. (B) Hypothalamic POMC mRNA is reduced by streptozotocin injection, but adrenalectomy completely blocks the reduction associated with streptozotocin. (C) Similar to AGRP, NPY mRNA is induced by streptozotocin injection and partially blocked by adrenalectomy. Data are expressed as mean percentage ± SEM of the control group. Data are expressed as mean ± SEM. Groups with different letters are statistically different (p < 0.05), reflecting ANOVA followed by Tukey-Kramer post hoc tests comparing every group to every other group. Thus groups with the same letter do not differ from each other at a p < 0.05 level.