Figure 8From: PI3K and PKC contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric veinThe PKC inhibitor chelerythrine, but not calphostin C, reduces the EFS-evoked slow membrane depolarization in canine isolated mesenteric vein. Intracellular recordings of membrane potential in response to EFS (0.1 ms, 13V, 10 s, 0.5 Hz) in control mesenteric veins (Control) or in tissues preincubated for 60 min with 1 μM chelerythrine (A) or 10 μM calphostin C (Calph C, B). The experimental data are presented as mean ± SEM, n = 3. *, P < 0.05 versus control. Scale bars apply to traces A and B.Back to article page