Figure 5
From: Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function
Serum protein levels of TNF, IL-1β and IL-6 in WT and C3H/HeJ mice following MI/R and 2 hours of reperfusion or sham operation determined with ELISA. All cytokines were significantly higher in WT mice which underwent MI/R compared to C3H/HeJ. TNF serum levels were 491.1 ± 138.6 pg/mL and 41.2 ± 9.6 pg/mL in WT MI/R and C3H/HeJ MI/R, respectively. IL-1β serum levels were 314.9 ± 76.3 pg/mL and 85.9 ± 32.2 pg/mL in WT MI/R and C3H/HeJ MI/R, respectively. Serum IL-6 was 1.6 times higher in WT (1890.6 ± 78.6 pg/mL) compared to C3H/HeJ (1178.1 ± 314.2 pg/mL). *p < 0.05 vs all groups, #p < 0.05 vs. WT sham.