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  1. Research article

    MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock

    MAPK-activated protein kinase 2 (MK2) plays a pivotal role in the cell response to (inflammatory) stress. Among others, MK2 is known to be involved in the regulation of cytokine mRNA metabolism and regulation ...

    Benjamin Vandendriessche, An Goethals, Alba Simats, Evelien Van Hamme, Peter Brouckaert and Anje Cauwels

    BMC Physiology 2014 14:5

    Published on: 4 September 2014

  2. Research article

    Impact of maternal dietary fat supplementation during gestation upon skeletal muscle in neonatal pigs

    Maternal diet during pregnancy can modulate skeletal muscle development of the offspring. Previous studies in pigs have indicated that a fat supplemented diet during pregnancy can improve piglet outcome, howev...

    Hernan P Fainberg, Kayleigh L Almond, Dongfang Li, Cyril Rauch, Paul Bikker, Michael E Symonds and Alison Mostyn

    BMC Physiology 2014 14:6

    Published on: 27 August 2014

  3. Research article

    Cardiac responses to elevated seawater temperature in Atlantic salmon

    Atlantic salmon aquaculture operations in the Northern hemisphere experience large seasonal fluctuations in seawater temperature. With summer temperatures often peaking around 18-20°C there is growing concern ...

    Sven Martin Jørgensen, Vicente Castro, Aleksei Krasnov, Jacob Torgersen, Gerrit Timmerhaus, Ernst Morten Hevrøy, Tom Johnny Hansen, Sissel Susort, Olav Breck and Harald Takle

    BMC Physiology 2014 14:2

    Published on: 1 March 2014

  4. Research article

    Kcnq 1-5 (Kv7.1-5) potassium channel expression in the adult zebrafish

    KCNQx genes encode slowly activating-inactivating K+ channels, are linked to physiological signal transduction pathways, and mutations in them underlie diseases such as long QT syndrome (KCNQ 1), epilepsy in adul...

    Calvin Wu, Kanishk Sharma, Kyle Laster, Mohamed Hersi, Christina Torres, Thomas J Lukas and Ernest J Moore

    BMC Physiology 2014 14:1

    Published on: 20 February 2014

  5. Research article

    Overtraining is associated with DNA damage in blood and skeletal muscle cells of Swiss mice

    The alkaline version of the single-cell gel (comet) assay is a useful method for quantifying DNA damage. Although some studies on chronic and acute effects of exercise on DNA damage measured by the comet assay...

    Bruno Cesar Pereira, José Rodrigo Pauli, LusâniaMaria Greggi Antunes, Ellen Cristini de Freitas, Mara Ribeiro de Almeida, Vinícius de Paula Venâncio, Eduardo Rochete Ropelle, Claudio Teodoro de Souza, Dennys Esper Cintra, Marcelo Papoti and AdelinoSanchez Ramos da Silva

    BMC Physiology 2013 13:11

    Published on: 8 October 2013

  6. Research article

    Dynamically regulated miRNA-mRNA networks revealed by exercise

    MiRNAs are essential mediators of many biological processes. The aim of this study was to investigate the dynamics of miRNA-mRNA regulatory networks during exercise and the subsequent recovery period.

    Alexander G Tonevitsky, Diana V Maltseva, Asghar Abbasi, Timur R Samatov, Dmitry A Sakharov, Maxim U Shkurnikov, Alexey E Lebedev, Vladimir V Galatenko, Anatoly I Grigoriev and Hinnak Northoff

    BMC Physiology 2013 13:9

    Published on: 7 June 2013

  7. Research article

    Significance of KATP channels, L-type Ca2+ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles In vivo

    ATP-sensitive K+ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca2+ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individu...

    AnhThuc Ngo, Mads Riemann, Niels-Henrik Holstein-Rathlou, Christian Torp-Pedersen and LarsJørn Jensen

    BMC Physiology 2013 13:8

    Published on: 12 May 2013

  8. Research article

    cAMP-stimulated Cl- secretion is increased by glucocorticoids and inhibited by bumetanide in semicircular canal duct epithelium

    The vestibular system controls the ion composition of its luminal fluid through several epithelial cell transport mechanisms under hormonal regulation. The semicircular canal duct (SCCD) epithelium has been sh...

    Satyanarayana R Pondugula, Suresh B Kampalli, Tao Wu, Robert C De Lisle, Nithya N Raveendran, Donald G Harbidge and Daniel C Marcus

    BMC Physiology 2013 13:6

    Published on: 27 March 2013

  9. Research article

    Quinine controls body weight gain without affecting food intake in male C57BL6 mice

    Quinine is a natural molecule commonly used as a flavouring agent in tonic water. Diet supplementation with quinine leads to decreased body weight and food intake in rats. Quinine is an in vitro inhibitor of Trpm...

    Philippe Cettour-Rose, Carole Bezençon, Christian Darimont, Johannes le Coutre and Sami Damak

    BMC Physiology 2013 13:5

    Published on: 8 February 2013

  10. Research article

    Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107–Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression

    SLC10A2-mediated reabsorption of bile acids at the distal end of the ileum is the first step in enterohepatic circulation. Because bile acids act not only as detergents but also as signaling molecules in lipid...

    Tohru Saeki, Kosuke Sato, Shiho Ito, Keisuke Ikeda and Ryuhei Kanamoto

    BMC Physiology 2013 13:4

    Published on: 4 February 2013

  11. Research article

    The antioxidant response of the liver of male Swiss mice raised on a AIN 93 or commercial diet

    Reactive oxygen species (ROS) are formed under natural physiological conditions and are thought to play an important role in many human diseases. A wide range of antioxidants are involved in cellular defense m...

    Aline C Caetano, Lucimara F da Veiga, Flávia R Capaldi, Severino M de Alencar, Ricardo A Azevedo and Rosangela MN Bezerra

    BMC Physiology 2013 13:3

    Published on: 24 January 2013

  12. Research article

    Genomic homeostasis is dysregulated in favour of apoptosis in the colonic epithelium of the azoxymethane treated rat

    The acute response to genotoxic carcinogens in rats is an important model for researching cancer initiation events. In this report we define the normal rat colonic epithelium by describing transcriptional even...

    Caroline A Kerr, Barney M Hines, Janet M Shaw, Robert Dunne, Lauren M Bragg, Julie Clarke, Trevor Lockett and Richard Head

    BMC Physiology 2013 13:2

    Published on: 23 January 2013

  13. Research article

    Disease resistance is related to inherent swimming performance in Atlantic salmon

    Like humans, fish can be classified according to their athletic performance. Sustained exercise training of fish can improve growth and physical capacity, and recent results have documented improved disease re...

    Vicente Castro, Barbara Grisdale-Helland, Sven M Jørgensen, Jan Helgerud, Guy Claireaux, Anthony P Farrell, Aleksei Krasnov, Ståle J Helland and Harald Takle

    BMC Physiology 2013 13:1

    Published on: 21 January 2013

  14. Research article

    VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity

    This work tests the hypothesis that bladder instillation with vascular endothelial growth factor (VEGF) modulates sensory and motor nerve plasticity, and, consequently, bladder function and visceral sensitivity.

    Anna P Malykhina, Qi Lei, Chris S Erickson, Miles L Epstein, Marcia R Saban, Carole A Davis and Ricardo Saban

    BMC Physiology 2012 12:15

    Published on: 19 December 2012

  15. Research article

    Localization of lipoprotein lipase and GPIHBP1 in mouse pancreas: effects of diet and leptin deficiency

    Lipoprotein lipase (LPL) hydrolyzes triglycerides in plasma lipoproteins and enables uptake of lipolysis products for energy production or storage in tissues. Our aim was to study the localization of LPL and i...

    Rakel Nyrén, Chuchun L Chang, Per Lindström, Anastasia Barmina, Evelina Vorrsjö, Yusuf Ali, Lisa Juntti-Berggren, André Bensadoun, Stephen G Young, Thomas Olivecrona and Gunilla Olivecrona

    BMC Physiology 2012 12:14

    Published on: 27 November 2012

  16. Research article

    Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue

    Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoproteins and makes fatty acids available for tissue metabolism. The activity of the enzyme is modulated in a tissue specific manner by interaction with ...

    Olessia Kroupa, Evelina Vorrsjö, Rinke Stienstra, Frits Mattijssen, Stefan K Nilsson, Valentina Sukonina, Sander Kersten, Gunilla Olivecrona and Thomas Olivecrona

    BMC Physiology 2012 12:13

    Published on: 23 November 2012

  17. Research article

    The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa

    Rescue or correction of CFTR function in native epithelia is the ultimate goal of CF therapeutics development. Wild-type (WT) CFTR introduction and replacement is also of particular interest. Such therapies ma...

    Torry A Tucker, James A Fortenberry, Akos Zsembery, Lisa M Schwiebert and Erik M Schwiebert

    BMC Physiology 2012 12:12

    Published on: 24 September 2012

  18. Research article

    High molecular mass proteomics analyses of left ventricle from rats subjected to differential swimming training

    Regular exercises are commonly described as an important factor in health improvement, being directly related to contractile force development in cardiac cells.

    Luiz A O Rocha, Bernardo A Petriz, David H Borges, Ricardo J Oliveira, Rosangela V de Andrade, Gilberto B Domont, Rinaldo W Pereira and Octávio L Franco

    BMC Physiology 2012 12:11

    Published on: 5 September 2012

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