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Table 1 Cosinor analysis on 24-h changes in hypothalamic NE content and DA turnover in young and old rats injected with Freund's adjuvant or its vehicle 18 days earlier.

From: Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats injected with Freund's adjuvant

 

Mesor

Amplitude

Acrophase (h, min)

Percent of rhythm

NE CONTENT

    

Anterior hypothalamus

    

Young, Freund's adjuvant

1030 ± 99

428 ± 34

12:36 ± 02:01

65 ± 12

Young, adjuvant's vehicle

1073 ± 113

444 ± 56

08:09 ± 02:35

51 ± 6.5

Old, Freund's adjuvant

803 ± 77*

499 ± 66

13:08 ± 02:13

48 ± 6.6

Old, adjuvant's vehicle

731 ± 98*

-

-

-

Medial hypothalamus

    

Young, Freund's adjuvant

661 ± 76

-

-

-

Young, adjuvant's vehicle

762 ± 55

225 ± 35

08:40 ± 02:08

44 ± 5.9

Old, Freund's adjuvant

618 ± 64

-

-

-

Old, adjuvant's vehicle

557 ± 43

285 ± 43

04:06 ± 02:34

70 ± 6.9

Posterior hypothalamus

    

Young, Freund's adjuvant

142 ± 32

55 ± 9

06:24 ± 02:44

49 ± 9.7

Young, adjuvant's vehicle

143 ± 13

62 ± 11

08:50 ± 02:03

81 ± 10.1

Old, Freund's adjuvant

143 ± 33

36 ± 4*

10:35 ± 01:33

53 ± 7.8

Old, adjuvant's vehicle

152 ± 27

38 ± 6*

11:26 ± 02:22

70 ± 9.2

DA TURNOVER

    

Anterior hypothalamus

    

Young, Freund's adjuvant

0.26 ± 0.01

-

-

-

Young, adjuvant's vehicle

0.27 ± 0.03

0.08 ± 0.01

06:51 ± 01:02

64 ± 3.4

Old, Freund's adjuvant

0.24 ± 0.02

0.05 ± 0.02

13:47 ± 01:47

59 ± 6.4

Old, adjuvant's vehicle

0.30 ± 0.01

0.05 ± 0.01

09:28 ± 02:21

53 ± 7.7

Medial hypothalamus

    

Young, Freund's adjuvant

1.04 ± 0.01

0.22 ± 0.03

20:17 ± 02:33

62 ± 7.7

Young, adjuvant's vehicle

1.16 ± 0.02

n.s.

n.s.

n.s.

Old, Freund's adjuvant

0.96 ± 0.02

n.s.

n.s.

n.s.

Old, adjuvant's vehicle

0.96 ± 0.03

-

-

-

Posterior hypothalamus

    

Young, Freund's adjuvant

0.34 ± 0.01

n.s.

n.s.

n.s.

Young, adjuvant's vehicle

0.38 ± 0.02

0.05 ± 0.02

09:20 ± 02:36

29 ± 4.4

Old, Freund's adjuvant

0.32 ± 0.02

n.s.

n.s.

n.s.

Old, adjuvant's vehicle

0.30 ± 0.01

0.07 ± 0.01

04:00 ± 01:35

39 ± 4.9

  1. Shown are the means ± S.E.M. (n = 5–7/group). Mesor and amplitude values are expressed as pg/mg (NE content) or as DOPAC/DA ratios. Percent of rhythm defines the part of variation that could be explained by a cosine function in Cosinor. Asterisks designate significant differences (p < 0.05) as compared to the respective young counterparts in a one-tailed Student's t test. n.s.: not significant daily changes in a oneway ANOVA; (-): not significant changes in Cosinor
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BMC Physiology

ISSN: 1472-6793

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