Figure 3From: Endothelial [Ca2+]i is an integrating signal for the vascular tone in rat aortaeAgonist-evoked EC [Ca2+]i elevation and vascular relaxation. Various combinations of endothelial autacoid inhibitors (10-4 mol/L L-NNA, 3 × 10-5 mol/L barium sulfate and 10-3 mol/L ouabain, and 10-5 mol/L indomethacin) were included in either ACh (a) or ionomycin (b) experiments to block various endothelial autacoids. (●): control in the absence of inhibitors; (○): contribution of NO in the presence of barium sulfate/ouabain and indomethacin; (Δ): contribution of L-NNA/indomethacin-insensitive dilatation in the presence of L-NNA and indomethacin; (*): contribution of PGI2 in the presence of L-NNA and barium sulfate/ouabain.Back to article page