Figure 6
From: Endothelial [Ca2+]i is an integrating signal for the vascular tone in rat aortae
Effects of PE and calcium-free Krebs-Ringer buffer on EC [Ca2+]i (●) and corresponding vasoconstriction (○). The aortic en face preparations were precontracted by 5 × 10-8 mol/L PE and subsequently exposed to calcium-free Krebs-Ringer buffer and 10-7 mol/L ACh (a). Experiments were carried out using intact preparation in the absence (a) or presence (b) of all endothelial autacoid inhibitors.