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Table 1 Effects of phenylephrine and calcium-free Krebs-Ringer buffer on EC [Ca2+]i and corresponding vasoconstriction.

From: Endothelial [Ca2+]i is an integrating signal for the vascular tone in rat aortae

 

Basal

PE (5 × 10-8 mol/L)

  

Normal

Ca2+-free

EC [Ca2+]i (nmol/L)

   

   - inhibitors

92.4+10.4

85.6+15.5

51.4+5.1*

   + inhibitors

80.0+15.2

83.8+9.9

53.5+10.3*

Contraction (%)

   

   - inhibitors

0

100

211.0+29.9*

   + inhibitors

0

100

103.3+1.6*#

  1. Results were taken from experiments similar to the one shown in Fig 4. Data are expressed as mean ± SE (n = 5). - inhibitors: without pretreatment of endothelial autacoid inhibitors + inhibitors: pretreatment with all endothelial autacoid inhibitors * P < 0.05 (Ca2+-free vs. normal buffer) # P < 0.05 (with inhibitors vs. no inhibitors)
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BMC Physiology

ISSN: 1472-6793

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