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Figure 4 | BMC Physiology

Figure 4

From: Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle

Figure 4

Voltage dependence of intramembrane charge movements in γ 1 knockout myotubes. A) Whole-cell current produced by charge movements in response to 3 of 14 25-ms voltage steps delivered to the same cell. The voltage steps shown are to -40 mV, +10 mV, and +70 mV. The cell capacitance was 241 pF for the control, 292 pF for the γ1 het and 253 pF for the γ1 null cell. B) Voltage dependence of charge movement obtained by integration of the OFF transient current for 8 control, 4 γ1 het, and 8 γ1 null cells. The curves correspond to a Boltzmann fit of the population mean with the following parameters. Qmax = 5.2 fC/pF, V1/2 = 13.2 mV and k = 9 mV for control cells. Qmax = 4.9 fC/pF; V1/2 = 15 mV and k = 14.5 mV for γ1 het cells. Qmax = 5.4 fC/pF, V1/2 = 19.6 mV and k = 16 mV for γ1 null cells.

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