Figure 3

Experimental timetable. A) The activity phase (17h-7h) and the resting phase (7h-17h) are represented in this schematic profile of body temperature variations of one animal during one day. The animals were followed for five weeks: one control week and four weeks with RSV supplementation (200 mg/kg/day). The mouse lemurs were fed daily one hour before the beginning of their active phase during the five-week study. Blood sampling and measurement of the resting metabolic rate (RMR) were carried out once a week (each one on a different day) during the control period and each week of RSV treatment during their daily resting period, 4-6 h after the beginning of the light period to minimize the influence of circadian variations. B) This long-term experimental time line shows when the telemetry surgery, acclimation and first experiments were performed. The telemetry surgery was performed two weeks before the beginning of the short day period to allow animals to recover before beginning the experiment. The white arrows represent the moment when blood sampling, measurement of resting metabolic rate (RMR) and body weight were undertaken (once a week). The body temperature (Tb) and locomotor activity (LA) were continuously recorded during the five weeks from the shift to short day period.