Figure 5

CK release (a), and cell necrosis (b) and apoptosis (c) in rat ventricular myocardium subjected to 90 min ischemia followed by 120 min of reoxygenation (n = 6/group). Specimens were incubated with SNAP or TRIM for 20 min prior to ischemia in the absences and presence of SB203580 (SB). For comparisons, some muscles were subjected to ischemic preconditioning (IP) in the absences and presence of SB203580. *P < 0.05 vs. ischemia/reoxygenation (I/R) alone.