Figure 7

Simulation of extracellular dehydration. Extracellular dehydration is preceded by a 24 h simulation performed under normal hydromineral conditions (control condition; A to F, solid black line; day 0). The simulated dehydration protocol is induced by two injections of furosemide along with a Na⁺ deficient diet (A to F, solid gray line, day 1). Cumulative urine excretion (E) and cumulative water intake (F) predicted at the end of day 0 are reported at the start of day 1. During the hydromineral challenge, the first injection of furosemide is given at the beginning of the simulation (8 AM, dotted line 1) and the second injection is given at 10 AM (dotted line 2). Ad libitum access to tap water is only permitted after the first 4 h of the simulation (dotted line 3) and the solid line 4 (panel B) indicates the threshold for drinking.