Table 1 List of the parameters and their physiological value used in the simulation.

ICF potassium concentration

[K⁺_ICF]

112 mmol/L

112 [12]

AVP concentration

[AVP] (t = 0)

1 pg/ml*

≈1 [19]; 1.05 ± 0.4 [11]; 1.7 ± 0.3 [23]; 1.9 ± 1.1 [46]

ECF Na⁺ concentration

[Na⁺_ECF] (t = 0)

140 mmol/L*

≈135 [17]; 138 ± 2.6 [22]; 143.3 ± 0.4 [37]; 145.6 ± 1.2 [23]); 146 ± .8 [47]

ECF volume

ECF_V (t = 0)

23 ml

23 [12]

ICF volume

ICF_V (t = 0)

46 ml

46 [12]

Rat weight

W

255 g*

150-250 [20]; 210-230 [23]; 245 ± 5 [24]; 250-280 [47]; 250-325 [48]; 262 ± 15 [22]

Sodium clearance

C_Na+

0.0086 ml/min

See Additional file 2[21–24]