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Table 3 Predictions of the hydromineral parameters obtained with the simulated extracellular dehydration protocol (furosemide injections combined with a Na+ deficient diet).

From: Computational simulation of vasopressin secretion using a rat model of the water and electrolyte homeostasis

Parameters

First 4 h (day 0)

Control

First 4 h (day 1)

Extracellular dehydration

24 h (day 0)

Control

24 h (day 1)

Extracellular dehydration

Mean ECF [Na+] over the period (mmol/L)

141.6

146.8

141.8

141.3

Mean [AVP] (pg/ml)

2.2

4.5

2.7

4.8

Mean ECF Volume (ml/100 g)

22.7

22.0

22.7

21.7

Mean ICF Volume (ml/100 g)

45.5

44.0

45.4

45.6

ECF [Na+] at the end of the period (mmol/L)

141.8

149.9

142.2

134.0

Cumulative Urine Na+ (mmol/100 g)

0.1

0.3

0.83

1.19

Water intake (ml/100 g)

0.1

3.5*

18.2

20.3

Na+ intake (mmol/100 g)

0.0072

0

0.74

0.41

Urine Volume (ml/100 g)

1.8

4.1

12.4

12.8

  1. Predictions at different time-points (4 h and 24 h) under control condition are listed under day 0 and predictions under Na+ deficit are listed under day 1. "*" indicates the amount of water ingested during the first 4 h after access to tap water (see the method for a detailed description of the protocol).