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Figure 1 | BMC Physiology

Figure 1

From: Increased expression and local accumulation of the Prion Protein, Alzheimer Aβ peptides, superoxide dismutase 1, and Nitric oxide synthases 1 & 2 in muscle in a rabbit model of diabetes

Figure 1

Increased expression of the Prion Protein (PrP), Superoxide dismutase 1 (SOD1), and Nitric oxide synthases 1 and 2, but not the Alzheimer Aβ precursor protein (AβPP), Presenilin 1 or BACE1 occurs in total muscle protein from diabetic rabbits. Immunoblot detection of proteins in diabetic and control muscle. A: PrP (MW ~30kDa, Epitomics), SOD1 (MW ~16kDa, Calbiochem), AβPP (MW ~110 kDa, Sigma), B: NOS1 (MW ~160 kDa, BD Biosciences), NOS2 (MW ~130 kDa, BD Biosciences), Presenilin 1 (MW ~52 kDa, Santa Cruz), BACE1 (MW ~55kDa, Santa Cruz) in total protein samples of quadriceps muscle from normal control (Con) and diabetic (Diab) rabbits. The doublet protein bands for PrP in diabetic and normal control muscle in Panel A is consistent with glycosylated forms, C: Densitometry measurements of protein bands shown on immunoblots above. Bar graphs show averages of the two band intensities with standard deviations. (NC: normal controls; D: diabetic).

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BMC Physiology

ISSN: 1472-6793

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