Table 2 Enriched biological processes showing dysregulation in zebrafish and mammalian obesity
From: Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
| Â | Zebrafish | Â | Rat | Â | Â | Mouse | Â | Human | Â | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Process | NES | MC | p-value | NES | MC | p-value | NES | MC | p-value | NES | MC | p-value |
Blood coagulation | 2.3 | 3.1 | 0.0E+0 | 2.0 | 1.1 | 0.0E+0 | 1.7 | 1.1 | 9.5E-3 | 1.8 | 1.5 | 0.0E+0 |
Platelet activation | 2.0 | 4.8 | 0.0E+0 | 1.8 | 1.1 | 6.1E-3 | 1.7 | 1.0 | 1.9E-2 | Â | Â | Â |
Fatty acid metabolism | 2.2 | 1.6 | 0.0E+0 | 1.8 | 1.0 | 0.0E+0 | 1.8 | 1.0 | 4.5E-3 | Â | Â | Â |
Cholesterol efflux | 1.6 | 1.1 | 0.0E+0 | 1.9 | 1.4 | 5.7E-3 | 1.8 | 1.3 | 0.0E+0 | Â | Â | Â |
Triglyceride metabolism | 1.8 | 2.0 | 0.0E+0 | 1.8 | 1.2 | 5.8E-3 | 1.7 | 1.1 | 9.5E-3 | Â | Â | Â |