Table 3 Regulatory factors involved in the coagulation cascade and lipid metabolism in zebrafish and mammalian obesity

Regulatory factor

p-value

Rank^a

p-value

Rank^a

p-value

Rank^a

p-value

Rank^a

APOH

1.9E-08

1

8.4E-16

1

2.4E-12

2

9.1E-11

4

IL-6

4.6E-05

3

6.5E-10

5

8.2E-09

7

4.5E-10

6

IL-1β

7.0E-05

6

1.2E-08

8

1.6E-07

16

8.4E-09

9

Lipid metabolism

Zebrafish

Rat

Mouse

Human

Regulatory factor

p-value

Rank^a

p-value

Rank^a

p-value

Rank^a

p-value

Rank^a

PPARα

1.6E-10

1

1.1E-23

1

9.1E-19

1

6.9E-24

1

PPARγ

1.7E-10

2

1.7E-15

3

2.1E-14

2

1.1E-16

3

NR1H3

1.0E-06

5

1.6E-15

2

2.7E-12

5

5.8E-17

2

LEP

1.8E-05

9

4.1E-10

13

3.7E-09

8

3.6E-12

10

SREBF1

1.8E-03

36

2.8E-13

7

5.7E-10

7

9.9E-10

15