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Table 3 Regulatory factors involved in the coagulation cascade and lipid metabolism in zebrafish and mammalian obesity

From: Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity

Coagulation cascade Zebrafish Rat   Mouse   Human  
Regulatory factor p-value Ranka p-value Ranka p-value Ranka p-value Ranka
APOH 1.9E-08 1 8.4E-16 1 2.4E-12 2 9.1E-11 4
IL-6 4.6E-05 3 6.5E-10 5 8.2E-09 7 4.5E-10 6
IL-1β 7.0E-05 6 1.2E-08 8 1.6E-07 16 8.4E-09 9
Lipid metabolism Zebrafish   Rat   Mouse   Human  
Regulatory factor p-value Ranka p-value Ranka p-value Ranka p-value Ranka
PPARα 1.6E-10 1 1.1E-23 1 9.1E-19 1 6.9E-24 1
PPARγ 1.7E-10 2 1.7E-15 3 2.1E-14 2 1.1E-16 3
NR1H3 1.0E-06 5 1.6E-15 2 2.7E-12 5 5.8E-17 2
LEP 1.8E-05 9 4.1E-10 13 3.7E-09 8 3.6E-12 10
SREBF1 1.8E-03 36 2.8E-13 7 5.7E-10 7 9.9E-10 15
  1. aRegulatory factors are ranked based on the p-value in each dataset.
  2. Regulatory factors ranked within the top 15 in at least three datasets are shown in this table.