Figure 5
From: VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
TRPV1-IR in the mouse urinary bladder. Representative photomicrograph illustrating distribution of TRPV1-IR in the urinary bladder isolated from C57BL/6 mice receiving chronic PBS instillation (A) shows TRPV1-IR extending from the base (cyan arrow) of the urothelium (white transversal bar) towards the sub-urothelium (yellow transversal bar). B) No immunostaining was observed in bladders isolated from TRPV1-/- mice indicating that this antibody specifically identifies TRPV1-IR nerve fibers. C indicates some TRPV1-positive nerves crossing the urothelial layer (white arrows) and D illustrates TRPV1-positive nerves surrounding urothelial cells. White waved line on D highlights the bladder lumen.