Figure 7
From: VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
Chronic BCG instillation increases IR for the pan neuronal marker, PGP9.5, and sensory nerve markers, TRPV1, SP, and CGRP. Quantification of PGP9.5- TRVP1-, SP-, and CGRP-IR in the sub urothelium (A) and detrusor muscle (B) of bladders isolated from: control (mice receiving i.p. PBS [twice a week] concomitant to 4 weekly instillations of PBS) and BCG-inflamed mice (mice receiving i.p. PBS [twice a week] concomitant to 4 weekly instillations of BCG). N = 8 per group. Statistical significance was set for p values < 0.05. NS = non significant.