Figure 9
From: VEGF signaling mediates bladder neuroplasticity and inflammation in response to BCG
Effect of NRP1 and NRP2 blocking antibodies on BCG-induced bladder nerve plasticity. Quantification of PGP9.5-IR (A-B) and TRPV1-IR (C-D) in the urinary bladder isolated from: control (mice receiving i.p. PBS [twice a week] concomitantly with 4 weekly instillations of PBS), BCG-treated (mice receiving i.p. PBS [twice a week] concomitant to 4 weekly instillations of BCG), NRP1A-BCG treated (mice receiving NRP1A [twice a week] concomitant to 4 weekly instillations of BCG), NRP1B-BCG treated (mice receiving NRP1B [twice a week] concomitant to 4 weekly instillations of BCG), NRP2-BCG treated (mice receiving NRP2B [twice a week] concomitant to 4 weekly instillations of BCG), and NRP2-PBS treated (mice receiving NRP2B [twice a week] concomitant to 4 weekly instillations of PBS). N = 8 per group. Statistical significance was set for p values < 0.05.