Figure 1

hAPP-expressing flies display age-dependent defects in climbing and flying. A. Climbing assays with wild type and LacZ expressing flies were performed every week. N = 136 and 85 for w¹¹¹⁸and LacZ expressing flies respectively. Mean +/- SEM. B. In order to measure the survival rates of flies, the numbers of w¹¹¹⁸and hAPP expressing transgenic flies were counted every week. Initially, 174 wild type and 166 transgenic flies were cultured. Mean +/- SEM. C. Climbing assays with w¹¹¹⁸and hAPP expressing transgenic flies in glass vials were conducted every week. N = 174 and 166 for wild-type and transgenic animals respectively. Mean +/- SEM. D. Flight assays with w¹¹¹⁸(light gray) and hAPP expressing flies (dark gray) were performed after five-week incubation in glass vials. Flies between 0-200 ml represent "poor fliers", while animals at 300-500 ml are designated as "good fliers". N = 131 and 90 for wild-type and transgenic animals respectively. Mean +/- SEM.