Figure 3
From: Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries
Role of the nitric oxide (NO)-cyclic GMP pathway in hypoxic vasodilation. (A) Concentration-response curves for NO in the absence and the presence of an inhibitor of soluble guanylyl cyclase, ODQ (3 × 10-6 M) in arteries contracted with endothelin or PGF2α. (B) Concentration-response curves for O2 lowering in the absence and the presence of an inhibitor of soluble guanylyl cyclase, ODQ (3 × 10-6 M) in arteries contracted with endothelin or PGF2α (C) Concentration-response curves for O2 lowering in the absence and the presence of an inhibitor of NO synthase, L-NOARG (3 × 10-4 M). Results are means ± SEM of 6 experiments. Differences were evaluated with two-way ANOVA with Bonferroni post-test: * P < 0.05, ** P < 0.01, ***P < 0.001 compared to control.