Effect of conditional c-myc deletion on liver regeneration. Male mice were subjected to 2/3 hepatectomy and assessed 24, 48, or 96 hr after resection. A. The graph shows liver:carcass weight ratio for c-myc+/+ (open bars) and c-mycfl/fl (closed bars) Alb-Cre expressing mice. The data are expressed as the mean + 1 SD. n ≥ 3 mice/group. B. Hepatocyte proliferation in duplicate c-myc+/+ and c-mycfl/fl Alb-Cre expressing mice 48 hr post-hepatectomy as assessed by Ki-67 immunohistochemistry. Representative 20× images are shown.