Cre expression in c-myc conditional knockout and control mice. A. Total liver RNA was isolated from male and female c-myc+/+;Alb-Cre+/+ (▲) and c-mycfl/fl;Alb-Cre+/+ (○) mice and cre expression assessed using RT-qPCR. Data are shown as individual points with the mean. *, P = 0.0303 4 wk c-mycfl/fl;Alb-Cre+/+ vs control. B. The correlation between cre expression and c-myc abundance in c-mycfl/fl;Alb-Cre+/+ expressing mice at 4, 8 and 10 weeks of age. Data are expressed as individual points. ◊, 4 weeks; ▲, 8 weeks; ○, 10 weeks.