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Figure 5 | BMC Physiology

Figure 5

From: The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa

Figure 5

Nasal Potential Difference is altered by ΔF508-CFTR in WT- CFTR/ΔF508-CFTR Heterozygous mice. A. Nasal Potential Difference Assays (NPD) were performed on the three genotypes of the ΔF508 mice: WT/WT, WT/ΔF, and ΔF/ΔF. NPD recordings were measured for each genotype in the presence of normal Ringer’s solution, low Cl- ringer’s solution, and then low Cl- Ringer’s solution containing the cAMP agonist salbutamol (100 μM) and adenosine (100 μM). B. Summary data of the results illustrated in A. C. Scatterplot representation of the NPD measurements performed in the 3 genotypes of the ΔF508 mice.

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BMC Physiology

ISSN: 1472-6793

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