Figure 9

GPIHBP1 distribution in islets and effects of diet, nutritional status and leptin deficiency. GPIHBP1 distribution in WT mice who were (A) fasted or (B) re-fed on normal chow. Mice put on a high fat diet for 10 days and then (C) fasted or (D) re-fed. (E-F) Other mice put on a high fat diet for 12 weeks compared to controls on chow. (G) GPIHBP1 distribution in ob/ob mice compared to (H) leptin treated ob/ob mice. The dotted lines indicate the islet borders.