Figure 11

The amplitude of voltage-gated Na⁺currents is increased in bladder sensory neurons isolated from VEGF-treated mice. A, Top panel presents the scheme of voltage protocol for recordings of voltage gated Na⁺ currents including depolarizing pulses from -70 mV to +60 mV ( 10 mV increments) from the holding potential of -70 mV. Lower panel shows representative raw traces recorded from VEGF group 2 weeks after the beginning of the treatment. B, Current-voltage (I-V) relationship of the total Na⁺ current recorded in bladder DRG neurons after intravesical application of VEGF (2 weeks). * - p≤0.05 when compared to control group.