TY - JOUR AU - Petsanis, Konstantinos AU - Chatzisotiriou, Athanasios AU - Kapoukranidou, Dorothea AU - Simeonidou, Constantina AU - Kouvelas, Dimitrios AU - Albani, Maria PY - 2012 DA - 2012/05/02 TI - Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5 JO - BMC Physiology SP - 5 VL - 12 IS - 1 AB - It is well known that axotomy in the neonatal period causes massive loss of motoneurons, which is reflected in the reduction of the number of motor units and the alteration in muscle properties. This type of neuronal death is attributed to the excessive activation of the ionotropic glutamate receptors (glutamate excitotoxicity). In the present study we investigated the effect of the NMDA antagonist DAP5 [D-2-amino-5-phosphonopentanoic acid] in systemic administration, on muscle properties and on behavioural aspects following peripheral nerve injury. SN - 1472-6793 UR - https://doi.org/10.1186/1472-6793-12-5 DO - 10.1186/1472-6793-12-5 ID - Petsanis2012 ER -