Skip to main content

Table 2 Summary of phenotype difference between Sox2-Cre:Errβ+/lox, Sox2-Cre:Errβlox/lox and Nes2-Cre:Errβlox/lox mice, relative to wild type (WT)

From: Estrogen-related receptor β deficiency alters body composition and response to restraint stress

Phenotype Sox2- Cre:Errβ+/lox Sox2- Cre:Errβlox/lox Nes2- Cre:Errβlox/lox  
Body Composition
Body weight ↑, ↓,
Fat mass ↑, ↓, NC
Lean mass ↓, ↓,
Hormone and Neuropeptides
Corticosterone ↑, ↓, NA
Corticosterone (DY131) ↑, ↓, NA
Crh expression ↑, ↑,
Crh expression (DY131) ↑↑, ↑↑, NA
Npy expression ↑, ↑,
Agrp expression ↑, ↑, NA
Stress Behavior
Acoustic startle response NA, NA,
Meal patterns
Total pellets consumed ↑, ↑, NC
Inter Meal interval (IMI) NC, ↓,
Satiety Ratio #, ↓,
  1. ↑ – increase, ↓ – decrease, NC – no change, ↑↑ – increase relative to levels with no DY131 treatment, NA – not available, #P = 0.05 relative to WT; Nes2-Cre:Errβlox/lox data adapted from [14].