Figure 7

Effect of feeding dietary oils on SIRT1 protein expression during postprandial lipemia. Samples of jejunum were collected following 1.5 h (for corn oil) or 2.0 h (for olive oil) administration in each of the oil groups. SIRT1 protein expression was examined using standard western blotting techniques. [A] SIRT1 protein expression is significantly diminished by feeding olive oil for 2 h (**P < 0.01 vs. WT + Saline control), a phenomenon that is attenuated in mice pre-treated with antibiotics and in TLR4^-/- mice (^#P < 0.05 vs. WT + Olive 2.0 h group). [B] Corn oil treated mice exhibited similar pattern of response but at different peak time points (1.5 h after gavage). (**P < 0.01 vs. WT + Saline control. ^#P < 0.05 vs. WT + Corn 1.5 h group).