Skip to main content
Figure 1 | BMC Physiology

Figure 1

From: Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107–Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression

Figure 1

Alignment of amino acid sequences of SLC10A family members and related proteins. The amino acid sequences of 10 of the related genes from bacteria, archaea, and plants that yielded the highest score by a BLAST search using the amino acid sequence corresponding to Gly104–Pro142 of mouse Slc10a2 (mSlc10a2) as a query sequence and the amino acid sequence of ASBTNM were compared with the amino acid sequences of SLC10A family members using the ClustalW software, and shading was rendered by the BoxShade program (http://www.ch.embnet.org/software/BOX_form.html). The alignments of the region corresponding to the query sequence are shown. The ASBTNM and mSlc10a2 sequences are boxed and the residues subjected to mutational analysis in this study and residues that have been reported to bind sodium via their side chains [20] are indicated by arrowheads and circles, respectively.

Back to article page

BMC Physiology

ISSN: 1472-6793

Contact us