Table 1 Plasma concentrations in study (starved, refed) and control mice (freely fed) from wild type and liver IGF-I knockout mice
Freely fed | Starved | Refed | Within groups p< | Among groups p< | ||
|---|---|---|---|---|---|---|
Glucose (mmol/l) | wt | 10.4 ± 0.5 | 8.0 ± 0.6 | 11.3 ± 0.4 | 0.05 | |
IGF- | 12.3 ± 1.2 | 8.1 ± 0.6 | 10.0 ± 0.8 | 0.05 | ns | |
Insulin (μg/l) | wt | 0.58±0.09 | 0.35±0.05 | 0.93±0.16 | 0.01 | |
IGF- | 1.11±0.26 | 0.43±0.07 | 0.98±0.20 | 0.05 | ns | |
IGF-I (μg/l) | wt | 172 ± 13 | 138 ± 13 | 159 ± 8 | ns | |
IGF- | 58 ± 7 | 40 ± 7 | 46 ± 7 | ns | 0.01 | |
GH (μg/l)a | wt | 2.0±0.8 | 5.1±2.1 | 12.6±7.3 | ns | |
IGF- | 11.5±8.5 | 15±6.1 | 17.6±11.3 | ns | ns |