Skip to main content

Table 1 Plasma concentrations in study (starved, refed) and control mice (freely fed) from wild type and liver IGF-I knockout mice

From: Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding

   Freely fed Starved Refed Within groups p< Among groups p<
Glucose (mmol/l) wt 10.4 ± 0.5 8.0 ± 0.6 11.3 ± 0.4 0.05  
  IGF- 12.3 ± 1.2 8.1 ± 0.6 10.0 ± 0.8 0.05 ns
Insulin (μg/l) wt 0.58±0.09 0.35±0.05 0.93±0.16 0.01  
  IGF- 1.11±0.26 0.43±0.07 0.98±0.20 0.05 ns
IGF-I (μg/l) wt 172 ± 13 138 ± 13 159 ± 8 ns  
  IGF- 58 ± 7 40 ± 7 46 ± 7 ns 0.01
GH (μg/l)a wt 2.0±0.8 5.1±2.1 12.6±7.3 ns  
  IGF- 11.5±8.5 15±6.1 17.6±11.3 ns ns
  1. Mean±SEM.
  2. A measured at 9 a.m.