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Table 2 Plasma amino acids in freely fed, starved and refed mice as described in material and methods

From: Liver-derived endocrine IGF-I is not critical for activation of skeletal muscle protein synthesis following oral feeding

  

Freely fed

Starved

Refed

Within groups p<0.05

Among groups p<0.05

  

μmol/liter

    

Essential AA

      
 

Isoleucine

wt

61 ± 6

56 ± 4

67 ± 9

ns

 

IGF-

59 ± 6

72 ± 7

50 ± 6

ns

ns

 

Leucine

wt

124 ± 17

84 ± 6

179 ± 29

0.05

 

IGF-

111 ± 12

114 ± 11

131 ± 20

ns

ns

 

Valine

wt

161 ± 16

120 ± 6

176 ± 20

ns

 

IGF-

152 ± 12

156 ± 13

143 ± 17

ns

ns

 

BCAA

wt

346 ± 38

260 ± 16

422 ± 58

0.05

 

IGF-

321 ± 28

342 ± 31

325 ± 43

ns

ns

 

Lysine

wt

258 ± 16

246 ± 16

277 ± 14

ns

 

IGF-

281 ± 21

282 ± 26

273 ± 21

ns

ns

 

Methionine

wt

55 ± 7

41 ± 5

97 ± 10

0.001

 

IGF-

48 ± 5

38 ± 3

77 ± 13

0.01

ns

 

Phenylalanine

wt

287 ± 37

389 ± 107

386 ± 93

ns

 

IGF-

402 ± 86

277 ± 36

311 ± 72

ns

ns

 

Threonine

wt

147 ± 14

119 ± 10

207 ± 13

0.05

 

IGF-

125 ± 7

114 ± 8

162 ± 20

0.05

0.05

 

Tryptophan

wt

34 ± 4

30 ± 3

42 ± 4

ns

 

IGF-

36 ± 3

35 ± 4

33 ± 3

ns

ns

 

Essential AA

wt

1127 ± 80

1086 ± 119

1433 ± 89

0.05

 

IGF-

1213 ± 112

1089 ± 70

1181 ± 91

ns

ns

Non-essential AA

      
 

Alanine

wt

337 ± 33

262 ± 37

547 ± 47

0.001

 

IGF-

283 ± 26

194 ± 13

459 ± 44

0.001

0,01

 

Arginine

wt

77 ± 12

20 ± 7

43 ± 10

0.01

 

IGF-

56 ± 14

41 ± 9

30 ± 10

ns

ns

 

Aspartic acid

wt

37 ± 6

34 ± 3

25 ± 3

ns

 

IGF-

22 ± 2

40 ± 6

33 ± 4

ns

ns

 

Asparagine

wt

31 ± 2

27 ± 2

41 ± 2

0.01

 

IGF-

25 ± 2

25 ± 1

32 ± 3

ns

0.01

 

Citrulline

wt

30 ± 3

20 ± 2

34 ± 2

0.01

 

IGF-

29 ± 2

20 ± 1

30 ± 3

0.01

ns

 

Glutamic acid

wt

166 ± 18

152 ± 16

129 ± 15

ns

 

IGF-

166 ± 11

138 ± 13

158 ± 23

ns

ns

 

Glutamine

wt

538 ± 36

520 ± 30

578 ± 31

ns

 

IGF-

553 ± 27

516 ± 42

560 ± 35

ns

ns

 

Glycine

wt

174 ± 18

170 ± 17

178 ± 10

ns

 

IGF-

150 ± 9

140 ± 15

175 ± 24

ns

ns

 

Histidine

wt

53 ± 4

50 ± 3

70 ± 4

0.01

 

IGF-

57 ± 4

52 ± 4

64 ± 4

ns

ns

 

Serine

wt

108 ± 12

85 ± 5

136 ± 5

0.01

 

IGF-

93 ± 16

75 ± 5

118 ± 9

0.01

ns

 

Tyrosine

wt

330 ± 23

395 ± 65

339 ± 82

ns

 

IGF-

323 ± 39

239 ± 40

285 ± 59

ns

ns

 

Ornitine

wt

88 ± 22

90 ± 12

109 ± 16

ns

 

IGF-

109 ± 16

83 ± 15

115 ± 10

ns

ns

 

α-Aba

wt

7 ± 1

8 ± 1

9 ± 1

ns

 

IGF-

6 ± 1

6 ± 1

8 ± 1

ns

ns

 

Non-ess. AA

wt

1977 ± 142

1835 ± 149

2237 ± 89

ns

 

IGF-

1872 ± 71

1570 ± 112

2065 ± 125

0.05

ns

 

Total AA

wt

3103 ± 219

2921 ± 264

3669 ± 143

0.05

 
  

IGF-

3085 ± 171

2659 ± 180

3246 ± 205

0.08

ns

  1. Mean±SEM.
  2. wt = wild type mice.
  3. IGF- = hepatic deficient IGF-I (−/−) mice.