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Figure 4 | BMC Physiology

Figure 4

From: Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line.

Figure 4

Tetraethylammonium does not block the ionic conductance in cGMP-activated AQP1 channels expressed in Xenopus oocytes.A. Recordings of current responses to voltage steps analyzed by two-electrode voltage clamp in an AQP1-expressing oocyte before stimulation (initial), after cGMP-dependent activation in 100 mM Na+ saline (activated) and after perfusion with saline containing 10 mM TEA and 90 mM Na+ (+TEA). No block of the ionic current was observed. B. Plot of the current-voltage relationship for data illustrated in (A). Conductance values calculated from linear fits of the data from -50 to +30 mV were 3.0 μS initial, 57.8 μS after activation in Na+ saline, and 57.3 μS with 10 mM TEA.

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BMC Physiology

ISSN: 1472-6793

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