Figure 4
Effect of high fat diet and adrenalectomy on oxygen consumption. Oxygen consumption (VO2 ) reflects metabolic rate normalized to body weight. (A) High-fat diet decreased VO2 in the sham-operated mice (chow sham-operated vs. diet sham-operated) statistically by ANOVA (p < 0.0001). (B) Adrenalectomy increased VO2 in diet-induced obese mice (diet sham-operated vs. diet adrenalectomized) by ANOVA (p < 0.05). Data are plotted as an average, within each group, of every five-minute interval between 18:00 hours and 12:00 hours.