Effect of carvedilol on cardiac myocyte apoptosis. Failinghearts treated with carvedilol show reduced number of TUNEL-positivenuclei, (A) DCM1 and (B) DCM20. Both low andhigh doses of the drug inhibited myocyte apoptosis to almost controllevels (C). No effect of carvedilol on apoptosis in control groupswas observed (C). *p < 0.001 vs. control and carvedilol treatedgroups. Micrographs in (A) and (B) were taken with 40X objectiveand reduced for reproduction.