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Table 1 Inhibition of Apoptosisby Carvedilol Correlates with Improvement in LV Function.

From: Chronic treatment with Carvedilol improves ventricular function and reducesmyocyte apoptosis in an animal model of heart failure

  Cont n = 13 Cont1 n = 11 Cont20 n = 10 DCM0 n = 18 DCM1 n = 13 DCM20 n = 12
FS % 68.73* ± 1.37 66.09* ± 0.90 66.99* ± 1.37 18.76 ± 1.83 27.73* ± 6.18 33.83* ± 10.11
Apoptosis % 1.72* ± 0.12 2.10 * ± 0.25 2.20* ± 0.24 5.64 ± 0.49 2.32* ± 0.23 2.36* ± 0.26
  1. Fractional shortening (FS%) was calculated fromechocardiographic images as described in the methods. Apoptoticnuclei were counted as described in methods. *p < 0.001 comparedto DCM0.