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Table 1 Inhibition of Apoptosisby Carvedilol Correlates with Improvement in LV Function.

From: Chronic treatment with Carvedilol improves ventricular function and reducesmyocyte apoptosis in an animal model of heart failure

 

Cont n = 13

Cont1 n = 11

Cont20 n = 10

DCM0 n = 18

DCM1 n = 13

DCM20 n = 12

FS %

68.73* ± 1.37

66.09* ± 0.90

66.99* ± 1.37

18.76 ± 1.83

27.73* ± 6.18

33.83* ± 10.11

Apoptosis %

1.72* ± 0.12

2.10 * ± 0.25

2.20* ± 0.24

5.64 ± 0.49

2.32* ± 0.23

2.36* ± 0.26

  1. Fractional shortening (FS%) was calculated fromechocardiographic images as described in the methods. Apoptoticnuclei were counted as described in methods. *p < 0.001 comparedto DCM0.