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Table 1 Mean (± SE) ionized calcium levels before (pre) and after (post) injection in wild type and Casr+/- mice. P values apply to the comparison of respective post versus pre values, and to the post values versus the corresponding post-saline value.

From: Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo

Genotype

Injection

Pre

Post

p value

Wild type

Saline (16)

1.28 ± 0.03

1.26 ± 0.02

-

Wild type

500 μmol/kg (13)

1.29 ± 0.02

1.34 ± 0.04

< 0.01

Wild type

5 mmol/kg (8)

1.29 ± 0.02

1.55 ± 0.06

< 0.01

Casr +/-

Saline (20)

1.42 ± 0.02

1.34 ± 0.04

-

Casr +/-

500 μmol/kg (25)

1.42 ± 0.02

1.50 ± 0.02

< 0.01

Casr +/-

5 mmol/kg (23)

1.40 ± 0.01

1.71 ± 0.03

< 0.01