Exploring hepatic hormone actions using a compilation of gene expression profiles

BMC Physiology

Table 1 Experiments included in the study.

species	age	sex	tissue	Control sample	Tester sample (hormone, time, dose)
rat	3 months	M	liver	c.i. of vehicle	c.i. of bGH, 1 week, 5 μg/h
rat	2 years	M	liver	c.i. of vehicle	c.i. of hGH, 3 weeks, 0.34 μg/g body weight/day
rat	2 months	M	hepatocytes	medium	bGH added to medium, 24 hours, 100 ng/ml
rat	3 months	M/F	liver	male	female
rat	3 months	M	liver	vehicle	17-α-ethinylestradiol, 1 day, 5 mg/kg body weight
mouse	3 months	M	liver	hypothyroid	injection of T3 & TT4, 2 hours, 5 μg T3 + 5 μg T4

Expression profiles from six independent studies regarding gender differences and hormonal regulation of hepatic gene expression were included in the study. bGH = bovine growth hormone, hGH = human growth hormone, T3 = triiodothyronine, T4 = thyroxine, c.i. = continuous infusion, hepatocytes = primary rat hepatocytes. All rat experiments used Sprague Dawley rat strain. The mice strain used to study thyroid hormone actions was a hybrid of 129/Sv X C57Bl76J.

ISSN: 1472-6793