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Table 4 Genes with a gender-differentiated expression pattern that were also affected in male rats continuously infused with GH.

From: Exploring hepatic hormone actions using a compilation of gene expression profiles

Unigene

Accession

Name

F/M

GH/untreated

Female predominant and up-regulated by continuous infusion of GH

Rn.3211

AW917574

similar to TNF ligand superfamily member 12

4.61

8.14

Rn.14535

AI070587

carboxylesterase 2 (intestine, liver)

3.54

4.57

Rn.53990

AJ302031

alpha-1-B glycoprotein

7.08

3.60

Rn.2586

NM_031572

Cytochrom P450 15-beta gene

4.72

3.08

Rn.115975

AW916713

EST sequence

5.61

2.85

Rn.2011

AA818134

peroxiredoxin 3

8.75

2.78

Rn.107116

AW142960

EST sequence

4.66

2.77

Rn.101709

AA819200

similar to Alcohol sulfotransferase (Hydroxysteroid sulfotransferase)

9.73

2.71

Rn.92406

AA819605

rat senescence marker protein 2A gene, exons 1 and 2

9.17

2.67

Rn.11377

AA875291

HRAS like suppressor

2.13

2.61

Rn.3790

L19658

cd36 antigen

5.81

2.39

Rn.91378

AA818024

sulfotransferase, hydroxysteroid preferring 2

7.53

2.35

Rn.32282

AI045872

arginine vasopressin receptor 1A

1.86

1.99

Rn.1292

AA858662

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

2.20

1.99

Rn.102325

AW917611

EST sequence

5.41

1.94

Rn.4000

X74402

guanosine diphosphate dissociation inhibitor 1

2.38

1.84

Rn.91122

AA858966

Cytochrome P450, subfamily IIC6

2.28

1.84

Rn.6946

AW140722

ferredoxin 1

2.28

1.79

Rn.8195

AW917572

EST sequence

3.61

1.68

Rn.106771

AA996745

similar to stromal interaction molecule 1

1.94

1.55

Rn.2180

CF108424

Atp5g3: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) isoform 3

1.86

1.53

Male predominant and down-regulated by continuous infusion of GH

Rn.1647

AF037072

carbonic anhydrase 3

0.06

0.09

Rn.37424

X79320

testosterone 6-beta-hydroxylase

0.10

0.15

Rn.23348

NM_031332

solute carrier family 22, member 8

0.10

0.16

Rn.103016

J00737

alpha-2u globulin PGCL1

0.01

0.18

Rn.106677

AA851893

similar to nucleoporin 37; nucleoporin Nup37

0.15

0.18

Rn.103770

CA504514

similar to Gelsolin precursor, plasma

0.19

0.22

Rn.888

AA819595

hydroxysteroid 11-beta dehydrogenase 1

0.12

0.31

Rn.7279

AF121345

phytanoyl-CoA hydroxylase (Refsum disease)

0.44

0.34

Rn.11320

CF110333

phosphoribosyl pyrophosphate synthetase 2

0.33

0.35

Rn.20403

CB805116

ectonucleotide pyrophosphatase/phosphodiesterase 2

0.22

0.36

Rn.106064

AW141056

similar to another partner for ARF 1

0.61

0.43

Rn.43232

AI045953

cysteine-sulfinate decarboxylase

0.27

0.54

Rn.22952

AW140875

putative homeodomain transcription factor 1

0.59

0.59

Rn.801

AW144321

EST sequence

0.48

0.59

Rn.6835

AA963739

similar to Putative lysophosphatidic acid acyltransferase

0.48

0.59

Rn.12345

AW916917

similar to RIKEN cDNA 6330575P11

0.48

0.64

Rn.93760

AA998734

glutathione S-transferase, mu 1

0.45

0.65

Male predominant but up-regulated by continuous infusion of GH

Rn.29771

AA900486

ATP citrate lyase

0.46

2.61

Rn.10992

AA964628

glucose-6-phosphatase, catalytic

0.48

2.10

Rn.98269

NM_145878

fatty acid binding protein 5, epidermal

0.63

2.03

Rn.9486

X62888

fatty acid synthase

0.56

2.36

  1. Differentially expressed genes were defined using SAM statistics, with a 5% false discovery rate as cutoff. An additional criterion was for the gene to have a mean ratio of at least 1.5. The table shows UniGene ID, GenBank accession number, gene name, and the median expression ratio (female/male or GH treated/untreated male).