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Table 5 Genes with a gender differentiated expression pattern that were also affected in male rats treated with 17-α ethinyl-estradiol (EE).

From: Exploring hepatic hormone actions using a compilation of gene expression profiles

UniGene

GBAccession

Gene Name

F/M

EE/untreated

Female predominant and up-regulated by ethinylestradiol

Rn.40365

AA819200

hydroxysteroid sulfotransferase subunit

9.73

3.39

Rn.40124

AA819605

Rat hydroxysteroid sulfotransferase a (STa) mRNA, complete cds

9.17

3.13

Rn.2011

AA818134

Peroxiredoxin 3

8.75

4.34

Rn.2151

AA818024

Rat hydroxysteroid sulfotransferase mRNA, complete cds

7.53

3.93

Rn.53990

AJ302031

Rattus norvegicus mRNA for putative alpha 1B-glycoprotein (ORF1)

7.08

1.53

Rn.102325

AW917611

Similar to Kruppel-like factor 7 (ubiquitous)

5.41

1.50

Rn.2586

NM_031572

Rattus norvegicus Cytochrom P450 15-beta gene (Cyp2c12)

3.89

1.74

Rn.4000

X74402

R. norvegicus rab GDI alpha mRNA

2.38

1.77

Rn.1247

AA818043

cytochrome P450, 2c39

2.31

5.72

Rn.7245

AA858966

Rat cytochrome P450 PB1 (PB1 allele) mRNA

2.28

3.39

Rn.17105

AI029316

ESTs, Highly similar to tetrahydrofolylpolyglutamate synthase

1.88

3.74

Rn.32282

AI045872

R. norvegicus mRNA for V1a arginine vasopressin receptor

1.86

1.79

Rn.2382

AA964489

R. norvegicus mRNA for C-CAM2a isoform

1.79

3.47

Rn.13801

AW142659

Amphoterin induced gene and ORF 3

1.69

1.78

Rn.23741

AA900073

ESTs, Weakly similar to Ser/ Thr protein phosphatase 5

1.59

2.35

Female predominant and down-regulated by ethinylestradiol

Rn.1292

AA858662

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

2.20

0.18

Rn.756

AA859785

Rat alcohol dehydrogenase (ADH) mRNA, complete cds

1.88

0.61

Rn.19721

U73174

glutathione reductase mRNA

1.64

0.43

 

X12367

glutathione peroxidase I

1.69

0.56

Male predominant and down-regulated by ethinylestradiol

Rn.1647

AF037072

carbonic anhydrase III

0.06

0.06

Rn.37424

U09742

CYP3A2 (testosterone 6-Beta-hydroxylase)

0.12

0.39

Rn.106677

AA851893

Similar to nucleoporin 37

0.15

0.16

Rn.102461

X16417

beta-globin

0.21

0.66

Rn.107334

NM_013096

Hemoglobin, alpha 1 (Hba1)

0.24

0.64

Rn.107335

AW142257

2-alpha globin; alpha-2-globin chain; hemoglobin alpha chain

0.28

0.59

Rn.100762

XM_235562

platelet-derived endothelial cell growth factor 1

0.42

0.33

Rn.7279

AF121345

peroxisomal phytanoyl-CoA hydroxylase (PHYH)

0.44

0.35

Rn.29771

AA900486

Rat ATP citrate-lyase mRNA, complete cds

0.46

0.32

Rn.15755

AW918421

EST

0.47

0.45

Rn.17644

AA817759

Peroxisomal Ca-dependent solute carrier-like protein

0.47

0.24

Rn.1086

AA817745

Adenylate kinase 4

0.52

0.57

Rn.5819

AA900928

Glutamic-oxaloacetic transaminase 1, soluble

0.53

0.58

Rn.9486

X62888

fatty acid synthase (EC 2.3.1.85)

0.56

0.34

Rn.48821

NM_012624

pyruvate kinase (L-type)

0.61

0.48

Rn.106064

AW141056

Similar to another partner for ARF 1

0.61

0.66

Rn.15739

M13508

apolipoprotein A – IV

0.62

0.53

Rn.10985

AW140851

choline kinase R; choline kinase R1

0.63

0.53

Rn.10389

AI058887

Rat p450Md mRNA for cytochrome P-450

0.65

0.54

Male predominant and up-regulated by ethinylestradiol

Rn.66254

AA817793

Glucose-6-phosphatase catalytic subunit 3

0.68

1.55

Rn.888

AA819595

Hydroxysteroid dehydrogenase, 11 beta type 1

0.12

3.17

  1. Differentially expressed genes were defined using SAM statistics, with a 5% false discovery rate as cutoff. An additional criterion was for the gene to have a mean ratio of at least 1.5. The table shows UniGene ID, GenBank accession number, gene name, and the median expression ratio (female/male or EE/Control male).
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BMC Physiology

ISSN: 1472-6793

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