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Figure 4 | BMC Physiology

Figure 4

From: PI3K and PKC contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric vein

Figure 4

The EFS-induced slow membrane depolarization of canine isolated mesenteric vein is reduced by various ion channel inhibitors. Intracellular recordings of membrane potential in response to EFS (0.1 ms, 13 V, 10 s, 0.5 Hz) in canine isolated mesenteric veins preincubated for 60 min prior to and throughout the experiment with 100 μM NFA (A), 30 μM NPPB (B), 200 μM DIDS (C) and 30 μM Gd3+ (D). The experimental data are presented as mean ± SEM, n = 3–4 (E). *, P < 0.05 versus control. Scale bars apply to traces A-D.

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