An extensive phenotypic characterization of the hTNFα transgenic mice

BMC Physiology

Table 3 Phenotypes in the Irwin observational panel

Observation	Genotype	Males	Females
Body weight (g)	WT	31.5 ± 18.8	20.3 ± 0.9
	TG	25.5 ± 1.7*	22.2 ± 0.9
Body length (mm)	WT	92.8 ± 0.9	86.6 ± 0.5
	TG	89.4 ± 1.0*	87.8 ± 1.1
Grip strength (score 0–4)	WT	2.4 ± 0.2	1.0 ± 0
	TG	0.8 ± 0.2**	1.6 ± 0.2
Wire maneuver (score 0–4)	WT	1.4 ± 0.2	2.8 ± 0.5
	TG	4.0 ± 0***	2.0 ± 0.6
Tail elevation (score 0–2)	WT	2.0 ± 0	1.4 ± 0.2
	TG	1.2 ± 0.2*	1.2 ± 0.2

Values represent the mean ± SEM n = 5 mice for each sex/genotype combination. The level of significance is shown by asterisks: * P < 0.05, ** 0.001 <P < 0.01, *** P < 0.001. For scoring description see Methods section for Irwin observational panel.

ISSN: 1472-6793