An extensive phenotypic characterization of the hTNFα transgenic mice

BMC Physiology

Table 5 Metabolic measures and activity measured in the CLAMS

Parameter	WT (n = 8)	TG (n = 6)	TG Percent of WT	WT (n = 7)	TG (n = 5)	TG Percent of WT
	HFD	HFD	HFD	RC	RC	RC
Oxygen consumption ml/kg/hr	2989 ± 93	3823 ± 110	128***	2770 ± 106	3454 ± 197	125**
Carbon dioxide production ml/kg/hr	2336 ± 114	2932 ± 124	124**	2510 ± 160	2985 ± 220	118*
Heat production Kcal/g	0.014 ± 0.001	0.018 ± 0.001	127***	0.014 ± 0.001	0.017 ± 0.001	123**
Respiratory exchange ratio	0.789 ± 0.015	0.764 ± 0.016	97	0.902 ± 0.036	0.856 ± 0.025	95
Ambulatory activity beam breaks/hr	1220 ± 65	458 ± 102	36**	1839 ± 283	448 ± 72	25***
Vertical activity beam breaks/hr	2124 ± 91	468 ± 133	21***	2550 ± 289	603 ± 166	22***

Values represent the mean ± SEM. The level of significance is shown by asterisks: * P < 0.05, ** 0.001 <P < 0.01, *** P < 0.001. HFD – high fat diet; RC – regular chow; TG percent of WT – measures of TG mice expressed as percent of the measures from the WT group.

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