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Table 1 Failure location of the bone-ligament-bone complex at 3 weeks post-injury.

From: Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments

Failure Location

Scar Region

Tibial Third of the Ligament

Tibial Avulsion

Sham Control

N/A

6

0

Amb + Saline

6

0

0

Amb + GH

6

0

0

Amb + IGF

5

1

0

Amb + GH + IGF

6

0

0

HU + Saline

5

0

1

HU+ GH

6

0

0

HU + IGF

5

0

1

HU+ GH + IGF

6

0

0

  1. The strong majority (>96%) of tissues failed in the ligament and not by avulsion, indicating that the measured mechanical changes are due to changes in the ligament properties and not bone.