Figure 6
From: Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation
Effect of different concentrations of PAR1-, PAR2-, and PAR4-AP on PMNs migration. Anesthetized female C57BL6 mice were catheterized, the bladder was emptied, and a volume of 200 μl of a solution of control peptide (10 μM) or PAR1-, PAR2-, and PAR4-AP at different concentrations (0.1 to 1000 μM) was instilled into the urinary bladder. The number of PMNs migration into the mouse bladders was examined 24 hours after instillation (n = 8 for PAR4-AP and control peptide and n = 4 for PAR1-AP and PAR2-AP).