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Table 3 Myocardial and serum TNF, IL-1β and IL-6 expression

From: Toll-like receptor 4 deficiency: Smaller infarcts, but nogain in function

A

    

Treatment

strain

TNF heart

IL-1β Heart

IL-6 heart

MI/R

WT

3.9 ± 0.7*#

6.9 ± 0.7*#

16.0 ± 3.2*#‡

 

C3H/HeJ

1.8 ± 0.7

5.7 ± 0.8*

8.0 ± 1.1*

Sham

WT

1.2 ± 0.6

2.4 ± 0.6

0.9 ± 0.2

 

C3H/HeJ

0.9 ± 0.4

3.1 ± 0.4

1.9 ± 0.2

B

    

Treatment

strain

TNF serum

IL-1β Serum

IL-6 serum

MI/R

WT

491.1 ± 138.6

314.9 ± 76.3

1890.6 ± 78.6

 

C3H/HeJ

41.2 ± 9.6

85.29 ± 32.2

1178.1 ± 314.2¥

Sham

WT

17.3 ± 7.2

17.3 ± 7.2

17.3 ± 7.2

 

C3H/HeJ

10.6 ± 3.2

26.0 ± 5.6

74.5 ± 23.1

  1. A Myocardial and B serum protein levels of TNF, IL-1β and IL-6 in WT and C3H/HeJ mice following MI/R and 2 hours of reperfusion or sham operation determined with ELISA. All serum cytokines were significantly higher in WT mice which underwent MI/R compared to C3H/HeJ. n = 5 for each group, *p < 0.05 vs C3H/HeJ sham, #p < 0.05 vs. WT sham, p < 0.05 vs C3H/HeJ MI/R, p < 0.05 vs all groups, ¥ p < 0.05 vs. WT sham and C3H/HeJ sham