Figure 5
Summary of hemodynamic data from the isolated heart perfusion evaluation of control and p57Kip2 overexpressing mice ( R26loxpTA-p57k/+;Mlc-2vCrek/+), at baseline and post ischemia/reperfusion (I/R). Left Ventricular Systolic Pressure (LVSP), Left Ventricular End Diastolic Pressure (LVEDP), Left Ventricular Developed Pressure (LVDP), Heart Rate (HR), Rate Pressure Product (RPP), LVdp/dt(max/min) and Coronary Flow (CF). LVDP, RPP and CF were better conserved in the transgenic hearts to a statistical significant degree compared to the hearts of wild type littermates (p < 0.05).